Guyandotte Wastershed
The Guyandotte River is a tributary of the Ohio River, approximately 166 mi (267 km) long, in southwestern West Virginia in the United States. It drains an area of the unglaciated Allegheny Plateau south of the Ohio between the watersheds of the Kanawha River to the northeast and Twelvepole Creek and the Big Sandy River to the southwest. Via the Ohio River, it is part of the Mississippi River watershed. The Mud River joins the Guyandotte at Barboursville in Cabell County.

Some of the featured rivers and streams of the Guyandotte Watershed are:
- Clear Fork River
- Twelve Pole River
- Beech Fork River